Abstract
Patients with high-risk lymphoma have a poor prognosis when treated with standard chemoimmunotherapy. This retrospective study included 23 high-risk lymphoma patients with a median age at diagnosis of 59 (range, 35–68) years. They received 2 cycles of R-COPADM and 2 cycles of CYVE, completed by ASCT for fit patients. With a median follow-up of 46 (range, 3–78) months, three (13%) patients in the cohort died. Nearly half of the patients had an ECOG performance status of 2 or 3. Most patients in the cohort (91%, n = 21) had Ann Arbor stage III-IV disease, and 88% (n = 20) had an IPI of 3 to 5. LDH levels were elevated in 83% (n = 19) of patients. Overall, 30% of patients were identified as having double-expressor lymphoma and 22% as having DHL, while two patients (9%) had THL. The origin of the lymphoma was GC B-cell-like in 15 patients (65%) and ABC-like in 8 patients (35%). Cumulative incidence of relapse at 46 months was 14% (95% CI, 5–37), while overall survival was 87% (95% CI, 64–95) and progression-free survival was 83% (95% CI, 60–93). These results showed the efficacy and an acceptable safety profile of the R-COPADM/CYVE/ASCT regimen in high-risk lymphoma, including patients with DHL.
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Data availability
The data sets generated and / or analyzed during the current study are available from the corresponding author on reasonable request.
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Acknowledgements
We thank the team of (Laboratoire d’Anatomie Pathologique, Hopital Saint-Antoine) for their dedication and help with the diagnosis of lymphoma patients.
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These authors contributed equally: Tamim Alsuliman, Nicolas Stocker
Authors and Affiliations
Sorbonne University, Paris, France
Tamim Alsuliman,Nicolas Stocker,Elise Corre,Rémy Dulery,Simona Sestili,Laure Ricard,Florent Malard,Mohamad Mohty,Paul Coppo&Zora Marjanovic
Service d’Hématologie Clinique et Thérapie Cellulaire, Hôpital Saint-Antoine, AP-HP, Paris, France
Tamim Alsuliman,Nicolas Stocker,Elise Corre,Rémy Dulery,Simona Sestili,Laure Ricard,Florent Malard,Mohamad Mohty,Paul Coppo&Zora Marjanovic
INSERM, UMRs 938, Centre de Recherche Saint-Antoine, Paris, France
Tamim Alsuliman,Nicolas Stocker,Elise Corre,Rémy Dulery,Simona Sestili,Laure Ricard,Florent Malard,Mohamad Mohty&Zora Marjanovic
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- Tamim Alsuliman
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- Nicolas Stocker
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TA, NS, and ZM designed the study, TA and NS collected the data, and all authors recruited patients. TA, NS, and ZM prepared the manuscript for publication. All authors analyzed the data, reviewed the manuscript, and agreed to its submission for publication.
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Correspondence to Zora Marjanovic.
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Alsuliman, T., Stocker, N., Corre, E. et al. Autologous hematopoietic cell transplantation as a part of a sequential multi-phase therapeutic approach (R-COPADM/CYVE/ASCT) as first-line treatment of high-grade B-cell lymphoma: results of a retrospective study with long-term follow-up. Bone Marrow Transplant 58, 437–439 (2023). https://doi.org/10.1038/s41409-022-01902-4
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DOI: https://doi.org/10.1038/s41409-022-01902-4
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